Located just north of Northgate (and colloquially considered part of it), 4405 College Main is completely abandoned, but it wasn't always that way. The building was built in 1985 according to Brazos CAD and was divided into two suites.
4405A was primarily a laundromat. The first one, College Main Wash & Go, only lasted until 1989 but it served as a laundromat sporadically over the years, including Come 'N Wash (2004-2005) and BV Washateria (2005-2009). There might've been something in the during the 1990s but research has been inconclusive at the latest update's press time. By 2014, it was converted into the i-Stop convenience store but by 2015, i-Stop had shriveled up, leaving the center completely empty.
At 4405B, the earliest restaurant I can find is Carrie's Kitchen in 1987, immortalized in the "Camptoons map" (from Carbon-izer) While I don't have phone books for the late 1980s (except 1989) readily available, it appeared that before the more well-known Thai Taste (which occupied B for most of the 1990s), "Carrie's Kitchen" was at 4405B in 1987 (and according to taxpayer records, only lasted a very short time). Thai Taste opened in 1990 and moved out to University Square in 2002. From what I've heard, Thai Taste was well-liked in this location, the University Square location, not so much. Details on Thai Taste are still sketchy, but I seem to remember from reading on forum postings that Thai Taste closed in the mid-2000s on College Main, but the name was bought and it reopened on University Square for a few years. Vietnamese Taste began operations in 2003 (keeping the "Taste" part of the old sign). Vietnamese Taste closed in May 2012 (roughly) and reopened as "Vy's Asian Kitchen Cuisine" just off Texas Avenue a few months later. It lasted another five years in that spot before changing hands; they must have done SOMETHING right.
After that, it was registered as "Bottoms Up" (presumably a bar) but Googling it just shows it as a taxpayer entity and not anywhere as an actual business. Despite "existing" for a year, this was probably just a stillborn business. With Vietnamese Taste having left in 2012 and never reopened, and the short rise and fall of I-Stop, the whole building has been vacant and is for sale. It can be yours for about $860k.
UPDATE 08-03-2021: New name, minor rewrite, new details, removing [2000s], [services], and [northgate], adding [defunct], [service businesses], and [college main].