In 1986, the downtown Safeway moved to 2001 Highway 21 to anchor a new shopping center, Culpepper North, presumably as a smaller companion to Culpepper Plaza. Unfortunately, it never gained more than a few stores and has been living with Family Dollar (not the original tenant) and another store space that has changed a few times over the years. As for the former Safeway, it was one of the last group of Houston Division Safeway stores to be built, and the very last AppleTree store to close. Read more about it on Safeway & Albertsons in Texas Blog. Today, the space is split between La Michoacana Meat Market and A&M Furniture.
UPDATE 04-08-2025: I came across some information that indicates the Family Dollar was originally Winn's Variety Stores but information is sparse. It did exist in the early 1990s, though. Additionally, the store between the two is Cricket (in 2007 this was a check cashing operation), A&M Furniture has since departed to the former Kroger (in the 99 Cents Only location), and according to the current PDF (see archive here). A&M Furniture has been replaced with a combo Family Dollar/Dollar Tree store. I have no idea if that's true or not as I haven't been in the area for a while and besides, Dollar Tree is offloading its sister chain to private equity. The reason I don't know is it also shows the rest of the space developed with a Murphy USA, which is not built yet (if ever). Also removed the 2019 update note.