I first stumbled upon this hotel (at 3610 Highway 6 South) in fall 2019 to find it closed despite being a fairly modern-looking hotel (it was built in 2005) and on the highway. All the signage was up and graffiti had not yet hit the building, but the high weeds and tattered entryway said otherwise, nor any sign that the hotel would be opening soon (it was removed from the Choice Hotels website). Apparently, the hotel closed by early 2018 (mentioned on Yelp's "Tips" which seem to have disappeared in a recent redesign) due to a flooding problem and it never reopened. At this rate I can't see it reopening as a Quality Suites any time soon, and even without a virus decimating tourist trades, there's a lot of hotel competition that didn't exist when Quality Suites first went up. Despite being on the freeway as well, its access is a bit difficult, either requiring the southbound exit to Texas and staying on the frontage road, or working around Longmire and going back to Ponderosa. There's a good chance that it was planned before the new Rock Prairie exit was made, not only did the old Rock Prairie exit actually allow access to the hotel very easily (even southbound) in 2005, it did not visually obscure it.
According to one of the old Choice Hotel locators I have (from 2007), the hotel has 81 rooms, a swimming pool, exercise room, meeting room, and a few other modest features (like guest laundry).
Even if the hotel industry was better (overbuilding had gotten to be a problem), Quality Suites shows no signs of reopening anytime soon. The card reader on the south entrance has been ripped out, exterior maintenance is slipping, rooms have been dismantled (mattresses leaning up, etc.), and the lobby is trashed. It would not take much to reopen it under a different name, but it requires some work that the current owners have not put in yet. Personally, I'm surprised the high weeds have not gotten the pressure from city code yet.
In terms of placement, this is the very first address (apart from Veronica's Country Corner, an outlier in every sense of the word) that focuses on a Highway 6 address that isn't on the Earl Rudder portion, and the first hotel covered in a while (not since La Quinta).
UPDATE 10-24-2023: In early 2023 this hotel reopened as Wingate by Wyndham. ([defunct] removed).
UPDATE 12-25-2023: I wanted to mention that the hotel is dual-branded as a Hawthorn Suites as well.